Intravenous immunoglobulin and immune response

Uses of intravenous immunoglobulin

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

Response to intravenous immunoglobulin predicts splenectomy response in children with immune thrombocytopenic purpura.

OBJECTIVE Response to intravenous immunoglobulin (IVIG) has been shown to predict response to splenectomy in adults with immune thrombocytopenic purpura (ITP). However, reports in children have been inconsistent. We sought to determine whether response to IVIG is predictive of response to splenectomy in children. METHODS Thirty-two assessable children were identified by a retrospective chart ...

Response of dystrophic calcification to intravenous immunoglobulin.

A 56-year-old woman with an 8-year history of CREST syndrome, a variant of scleroderma, presented with increasing calcium deposits that were causing inflammation and swelling of the index finger of her left hand (Figure 1), as well as Raynaud phenomenon, telangiectasia, and mild sclerosis of her fingers. She had intense pain and extreme morbidity and was severely handicapped in her office job. ...

Modulation of adaptive immune response following intravenous immunoglobulin therapy in common variable immunodeficiency.

C ommon variable immune deficiency (CVID) is the most frequent symptomatic primary immune deficiency in adults with a prevalence of approximately 1 in 25,000 in the general population [1]. Indeed patients frequently become symptomatic later in life; however, their clinical history may reveal features of the disease dating back to early childhood. The disorder is characterized by recurrent and/o...

Mechanism of action of intravenous immunoglobulin in immune-mediated cytopenias.